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HIFU Treatment Guide

HIFU for fibroids & adenomyosis

Learn how focused ultrasound treatment for fibroids works, compare adenomyosis treatment options, and prepare questions for a specialist.

Chinese specialist discussing imaging with an international patient during consultation
Illustration: discussing imaging at a consultation
HIFU treatment room with the ultrasound system and monitoring console
Illustration: a focused ultrasound treatment room
Clinical team in the HIFU treatment suite
Illustration: a clinical team in a treatment setting

How HIFU works

High-intensity focused ultrasound (HIFU) directs sound energy from outside the body toward selected tissue. A specialist reviews imaging to decide whether a fibroid or adenomyosis lesion can be treated this way.

  • FocusedEnergy aimed at the target
  • ImagingPlanning and monitoring
  • 0Incisions
  • ImagingTreatment guidance
How focused ultrasound works: an external transducer converges ultrasound energy onto the target lesion, with no incisions.

Sound passes through the skin

The device sends ultrasound from outside the body, so treatment does not require a skin incision. The hospital checks whether the beam path is suitable.

Energy heats the target

Focused energy heats selected tissue. The clinical team adjusts treatment using its imaging and monitoring protocol.

Nearby tissue needs protection

Planning aims to limit exposure of surrounding organs, but complications can still occur. Ask how risks are managed for your anatomy.

Follow-up checks the response

Treated tissue may change or shrink over time. Follow-up imaging and symptoms help the specialist assess the result.

Understanding your diagnosis

Medicines and hormonal treatments may help manage bleeding or pain from fibroids or adenomyosis. Benefits and side effects vary by treatment and person. If symptoms remain difficult to manage, ask a specialist about uterus-sparing procedures and surgical options.

Uterine fibroids

Your specialist will review your symptoms and imaging before discussing whether HIFU is an option.

Adenomyosis

Ask your specialist how your diagnosis affects the treatment choices and expected symptom relief.

Compare your options

QuestionHIFUMyomectomyHysterectomy
ApproachHigh-Intensity Focused Ultrasound (HIFU)Surgical fibroid removalSurgical uterus removal
UterusRetainedRetainedRemoved
Future pregnancyEffects remain uncertainDiscuss risks and timingCannot carry a pregnancy
Incision / scarringNo skin incisionDepends on hysteroscopic, laparoscopic or open approachDepends on vaginal, laparoscopic or open approach
AnaesthesiaHospital-specific sedation planDepends on the surgical and anaesthesia planDepends on the surgical and anaesthesia plan
Hospital stayMay be outpatient; hospital decidesOften inpatient; depends on surgical approachUsually inpatient; depends on surgical approach
Return to workAsk about your own recovery planRecovery varies with surgical approachRecovery varies with surgical approach
Conception waiting periodIndividual specialist advice; evidence remains uncertainDepends on surgery and healing; ask your specialistPregnancy not possible

Ask about non-surgical options too. The right choice depends on your symptoms, diagnosis and priorities.

What the hospital reviews

Imaging

Recent MRI or ultrasound and any additional tests requested by the hospital.

Medical history

Previous procedures, medicines and any other health conditions.

Symptoms

Bleeding, pain and how symptoms affect your daily life.

Your priorities

Pregnancy plans, treatment preferences and recovery needs.

Treatment day & your stay

Plan time for hospital assessment, treatment if suitable, observation and a discharge review. Your hospital will confirm the schedule before you travel.

Treatment session

The procedure and its duration depend on your imaging, treatment plan and hospital protocol.

Observation & discharge

The team checks your condition after treatment and decides when you can safely leave the hospital.

Recovery at home

Ask your hospital when you can return to daily activity, work and exercise; recovery varies by person.

Follow-up schedule

Ask which symptom reviews and imaging checks you need after returning home, especially if you plan pregnancy.

Questions about the treatment

Am I a candidate for HIFU?

Fibroids: HIFU may suit intramural, subserosal and selected submucosal fibroids, whether single or multiple, when the lesion is at least 2 cm and has a safe ultrasound path. It is worth considering if heavy or prolonged periods, anaemia, pelvic pressure, urinary frequency or constipation affect you, or if you want to preserve your uterus or have fibroids after a previous myomectomy.

Adenomyosis: Both focal adenomyoma and diffuse adenomyosis can be assessed for HIFU, with relief of painful or heavy periods and chronic pelvic pain as the goal. It may also be an option if medication is hard to tolerate or a Mirena device has been expelled. Your doctor can use your imaging and symptoms to advise whether HIFU suits you.

When is HIFU not suitable?

HIFU is not suitable during pregnancy, with an active pelvic or genital infection, or when bowel or bone blocks a safe ultrasound path. A lesion suspicious for cancer needs investigation first.

Severe bleeding disorders, serious liver or kidney disease, inability to stay in the required position or communicate during treatment, and some implanted devices can also rule it out or require preparation. Tell the team about any IUD, pacemaker or breastfeeding. Your doctor can confirm which of these applies to you.

Which symptoms can HIFU improve?

Fibroids: HIFU can ease heavy or prolonged periods and pressure symptoms such as pelvic fullness, lower back discomfort, urinary frequency and constipation. Anemia may improve as bleeding falls, though it may also need separate treatment.

Adenomyosis: HIFU can relieve painful or heavy periods, chronic pelvic pain and pain during sex. Some patients also see a reduction in uterine size. Your doctor can tell you which symptoms are most likely to improve in your case.

Which lesion types respond best?

Fibroids (from better to more challenging candidates): Intramural and broad-based subserosal fibroids often respond well. With multiple fibroids, treatment can focus first on the larger lesions causing symptoms. Fibroids that appear after laparoscopic or open myomectomy are also worth assessing, since HIFU does not require another abdominal operation; the scar and ultrasound path still need checking. For 5–10 cm fibroids, GnRH-a may be used first to reduce size; those over 10 cm may be assessed for treatment in stages. Small, thin-stalked submucosal fibroids under 3 cm are often better treated by hysteroscopy.

Adenomyosis: A well-defined focal adenomyoma is easier to target; for diffuse adenomyosis, the goal is symptom relief rather than complete removal. Treatment may reduce uterine size and may help with Mirena retention. Cellular, T2-bright or very vascular fibroids are more challenging and may need medication beforehand. Your doctor can assess the likely response from your imaging.

HIFU vs surgery — how do I choose?

HIFU treats the fibroid without an abdominal incision and preserves the uterus. Laparoscopic or open myomectomy removes the fibroid and also preserves the uterus, but new fibroids can develop and symptoms can return after either operation. HIFU can also need further treatment if symptoms persist or return.

The practical differences are whether the fibroid is ablated or removed, whether an incision is needed, and the recovery and risks of each approach. Hysterectomy removes the uterus and therefore the possibility of future uterine fibroids, but it is a different decision from choosing between HIFU and myomectomy. Your doctor can compare these options for your lesions and priorities.

Guidance & references

Published guidance can help you prepare questions for a specialist. It does not determine whether HIFU is right for you.

Chinese expert consensuses discuss fibroids, adenomyosis and focused ultrasound practice. NICE published guidance for symptomatic fibroids in 2019 (IPG657, now HTG523); it says evidence on efficacy is limited in quality and calls for special arrangements for governance, consent and audit or research.

Selected references

  1. Chinese expert consensus on the diagnosis and treatment of uterine fibroids. Chin J Obstet Gynecol. 2017;52(12):793-800. ↗
  2. Chinese expert consensus on the diagnosis and treatment of adenomyosis. Chin J Obstet Gynecol. 2020;55(6):376-383. ↗
  3. Expert consensus on the clinical technical standards for focused ultrasound ablation (2020 edition). Natl Med J China. 2020;100(13):974-977. ↗
  4. Image-guided therapies for uterine fibroids. Int J Gynaecol Obstet. 2025 (FIGO). ↗
  5. Zhang L, Zhang W, Orsi F, et al. Ultrasound guided high intensity focused ultrasound for the treatment of gynaecological diseases: a review of safety and efficacy. Int J Hyperthermia. 2015;31(3):280-284. ↗

HIFU side effects, risks & uncertainty

Symptoms may persist or return, and further treatment may be needed. Possible complications include pain, skin burns, bleeding or discharge and, rarely, injury to nearby organs. Effects on fertility and future pregnancy remain uncertain.

NICE guidance on ultrasound-guided HIFU for uterine fibroids ↗

This guidance addresses uterine fibroids; discuss adenomyosis separately with your specialist.

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